KULLIYYAH OF PHARMACY

KULLIYYAH OF PHARMACY

Research Groups

Research Groups


Background

Pharmacognosy is a science that focuses on molecules and involves isolation and determination of the structure of pharmacologically active molecules as well as the study of their biosynthesis, including the enzymes and the genes which are involved. It is extended to a big data analysis to connect between bioactivity, metabolites, and drug sources. Our current performance is indicated as follows. 

Background

Substance Use Disorder (SUD) is a growing public health problem that occurs worldwide and yet there is still no concrete approach in curbing such predicament. The development of related studies especially on pharmacological interventions seems to be decelerated could be due to the lack of interest from the researchers or profit gained from this population. Patients with SUD are more than always received stigmas and negative perceptions form the community they lived in or even from the healthcare practitioners where this population has been associated with violence, crime, misbehaviour and threat to the community that impede healthcare delivery towards them.

Scope of Research Activities

  • Evaluation on the actual burden of SUD disease in our country both for illicit (amphetamine, marijuana, ketum, etc) and prescription drugs.
  • Longitudinal evaluation on the outcomes of current treatment approach (patient, community and national level).
  • Investigation on the effectiveness of methadone maintenance therapy (MMT) program in this country as one of the harm reduction approaches.
  • Identification of possible other treatment approach or strategy in the pipeline to be further developed (eg: PK/PD approach /opioid vaccine).
  • Overviewing, proposing and improving current policy regarding SUD.
  • Identify the potential drug target to treat poly-drug addiction using pharmacological approach.
  • Identify potential compounds in local plants that can be developed to treat drug addiction.


Leader and Members

  • Dr Nor Ilyani Mohamed Nazar. (Leader)
  • Dr Che Suraya Haji Mohd Zin.
  • Dr Mohamad Haniki Nik Mohamed.
  • Dr Norny Syafinaz Ab Rahman.
  • Dr Nor Hidayah Mohd Taufek.
  • Dr Irna Elina Ridzwan.
  • Mdm Siti Halimah Bux Shaikh Rahman Bux.
  • Dr Wael Mohamed Yousef Mohamed (KOM)





Background

Quality Use of Medicines (QUM) refers to the selection of suitable therapeutic interventions followed by assuring the safe and cost-effective use of medicines. The World Health Organization have identified improved patient safety in healthcare as a priority. Pharmacists, in particular, have a key role in ascertaining the quality of medications used for patients, especially in vulnerable populations and patients with chronic diseases. Our research group is more practice-oriented that covers all aspects of quality use of medicines. The current research involves but not limited to the use of medicines in geriatrics and patients with diabetes, cardiovascular diseases, infectious diseases, and psychiatric illness. 

Scope of research activities

  1. To assess the quality of use and prescribing of medicines in healthcare settings.
  2. To describe and assess patterns of medication use and prescribing.
  3. To investigate the barriers and facilitators towards quality use of medicines.
  4. To conduct interventional studies to improve the quality of medication use and prescribing in healthcare settings.
  5. To promote and assess the awareness towards medication adherence, medicines information sources and health literacy.
  6. To investigate and assess pharmacists’ competencies, education and training that deemed necessary to perform their role in the quality use of medicines.

Leader and members

  • Asst. Prof. Dr. Mohamed Hassan Elnaem (Leader)
  • Assoc. Prof. Dr. Mohamad Haniki Nik Mohamed
  • Asst. Prof. Dr. Muhammad Eid Akkawi
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas
  • Asst. Prof. Dr. Nor Hidayah Mohd Taufek
  • Asst. Prof. Dr. Nor Ilyani Mohamed Nazar
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Siti Hadijah Binti Shamsudin
  • Asst. Prof. Dr. Abdulkareem Mohammed Al-Shami
  • Asst. Prof. Dr. Tengku Karmila Tengku Kamil

Background

Research methodology is the overall plan ‘that shapes our choice and use of particular methods and links them to the desired outcomes’. Qualitative research is complementary in evaluating the in-depth standpoints and diverse opinions of healthcare practitioners on patient safety, patient advocacy and patient centered care. Qualitative research imparts more flexible meaning, generally emerge from stakeholders’ direct experiences either from their daily lives or professional practices. 

Scope of research activities

  1. Rigor in Qualitative Research Instrument
  2. Patient- Centered Care through Action Research
  3. Patient Safety through Social Phenomenological Approach
  4. Cultural Competence in Healthcare through Participatory Action Research
  5. Stakeholders Observation on Quality of Life in Patients having Non-communicable Diseases

Leader and members

  • Asst. Prof. Dr. Shazia Jamshed (Leader)
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Abdul Kareem Mohammed Al Shami
  • Assoc. Prof. Dr. Hazrina Hadi
  • Asst. Prof. Dr. May Khin Soe 
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas

Background

This proposal aims to seek an approval from Kulliyyah of Pharmacy Board ( IIUM ) for establishment of Toxicology research group. Toxicology is an integrated discipline that focuses on effects of xenobiotics to living creatures and environment. The group core strength will be mechanistic toxicology on natural toxins, commonly used herbs and conventional drugs. The group will employ traditional toxicology techniques as well molecular techniques to elucidate mechanism of toxicities. 


Scope of research activities 

i. Isolation and characterization of venom and toxins.

ii. Proteomic study of venom and toxins.

iii. Neurotoxicity and cardiotoxicity studies for venom and toxins.

iv. Nephrotoxicity studies of drug-drug, drug-herbal interactions.


Leader and members

  1. Assoc. Prof. Dr. Abdul Razak Kasmuri.
  2. Asst. Prof. Dr. Muhamad Rusdi Ahmad Rusmili.
  3. Asst. Prof. Dr. Che Anuar Che Muhammad.
  4. Asst. Prof. Dr. Rosazra Roslan.
  5. Asst. Prof. Dr. Nurul Asyiqin Yusof.
  6. Asst. Prof. Dr. Zalikha Ibrahim.

Background

The potential of the domestic pharmaceutical industry has been recognised by the Malaysian government as a strategic industry that should be promoted.  In consistent with this aspiration, the Kulliyyah of Pharmacy, IIUM has designated industrial pharmacy as one of its niche areas to assist in the development of the required human capital and the provision of the relevant new knowledge through research.  One way of promoting high quality research and enhancing good research image of the university is to establish a well-balanced team of researchers through the so-called research clustering.  Hence, the establishment of a research cluster at the Kulliyyah of Pharmacy, which focuses in the area of industrial pharmacy, is the way forward.    

Objectives:

  • Form a pool of researchers with diverse expertise enabling complementary researches in pharmaceutical development and production;
  • Promote researches addressing emerging problems in pharmaceutical development and production with the ultimate aim of improving quality of life; and
  • Provide scientific support to fledging pharmaceutical industries through collaborative research and consultation service.

Leader and Members

Siti Hadijah Shamsuddin

Post Graduate Students in Masters in Pharmaceutical Sciences

  • Thazin Win (PhD)
  • Rana Samour (PhD)
  • Aina Mardiah bt Sabar (MSc)
  • Nur ‘Abidah Mohamed Nasir (PhD)
  • Shaiqah Mohd Rus (PhD)
  • Hamzeh Al Khatib (PhD)
  • Md. Abul Kalam Azad (Phd)
  • Samah Hamed Abdulrahman Almurisi (Phd)
  • Nur Ain Binti Ayob (Phd)
  • Alallam Batoul (Msc)
  • Luqman Muizzuddin Bin Mohd Rosli (Msc)   

Laboratory(s) and facility(s)
Instrumentation Lab, Advanced Drug Delivery (ADD)S Lab, Dosage Design Lab, Animal Cell Culture, Cosmetic Laboratory
 
Link and Collaboration

  • Universitas Muhammadiyah, Jogjakarta
  • Universitas Islam Indonesia, Jogjakarta
  • Alfaisal University (Riyadh, Saudi Arabia)

Community Services

  • Training on Good Manufacturing Practice
  • Hand sanitiser preparation and Distribution Covid 19 (2000 bottles) 16-17 March 2020.

Research Grant

  • Prototype Research Grant Scheme (PRGS-2019) Production of Hydrogel Sheet Containing Centella asiatica (pegaga) for wound healing.
  • Microencapsulation of royal jelly in alginate beads using electrospray: a quality-by-design (QbD) approach. (IRAGS 2018) (RM 20,000)
  • Elucidating the anti-cancer Mechanism of thymoquinone nanoparticles involving the MAPK signaling pathway in zebrafish xenografts of colonic and melanoma cancers. in vitro & in vivo study. (FRGS 2017) (RM 88,400)
  • Prototype development of process analytical technology (PAT) continuous production line for Nigella sativa oil (NSO)-alginate microparticles. (PRGS 2019) (RM 116,000)
  • Reproducible Preparation of Thymoquinone Nanoparticles Using Electrospray. (P-RIGS 2018) (RM 20,000)
  • Black Seed Oil Alginate Beads. (Smart Challenge Fund 2018) (RM 871,750)

List of Selected Publications 

  • Hassani, A., et al., Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin. Molecules, 2020. 25(9): p. 2244.
  •  Azad, A.K., et al., Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study. Pharmaceutics, 2020. 12(3).
  •  Almurisi, S.H., et al., Taste masking of paracetamol encapsulated in chitosan-coated alginate beads. Journal of Drug Delivery Science and Technology, 2020. 56.
  •  Mawazi, S.M., et al., Carbamazepine Gel Formulation as a Sustained Release Epilepsy Medication for Pediatric Use. Pharmaceutics, 2019. 11(10): p. 488.     
  • Wan Salleh, Wan Mohd Nuzul Hakimi and On, Shamsul and Ahmad, Farediah and Mohd Sirat, Hasnah and Bakhtiar, M. Taher and Sarker, Satyajit Dey and Nahar, Lutfun (2020) A new xanthone and a new benzophenone from the roots of Garcinia hombroniana. Phytochemistry Letters, 35. pp. 216-219
  • Ayumi, Rasyidah Ryta and Shaik Mossadeq, Wan Mastura and Zakaria, Zainul Amiruddin and Bakhtiar, M. Taher and Kamarudin, Nadhirah and Hisamuddin, Nadia and Talib, Madihah and Sabar, Aina Mardhiah (2020) Antinociceptive activity of asiaticoside in mouse models of induced nociception. Planta Medica
  • Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati (2019) Prediction of mefenamic acid solubility and molecular interaction energies in different classes of organic solvents and water. Industrial & Engineering Chemistry Research, 58 (2). pp. 762-770. ISSN 0888-5885
  • Akanda, Md Jahurul Haque and Sarker, Md. Zaidul Islam and Beh, Leykey and Sharifuddin, Md Shaarani and Siddiquee, Shafiquzzaman and Mamat, Hasmadi and Sahena, Ferdosh and Abdul Hamid, Mansoor and Lee, J. S. and Jinap, Selamat(2019) Valuable components of bambangan fruit (Mangifera pajang) and its co-products: a review. Food Research International, 115. 105 -115. ISSN 0963-9969
  • Hassan, Syajaratul Jahriah and Adam, Fatmawati and Abu Bakar, Mohd Rushdi and Abdul Mudalip, Siti Kholijah (2019)Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals. Journal of Saudi Chemical Society, 23 (2). pp. 239-248. ISSN 1319-6103
  • Jaswir, Irwandi and  Dedi Noviendri and Bakhtiar, Muhammad Taher and Mohamed, Farahidah and Octavianti, Fitri andLestari, Widya and Mukti, Ali Ghufron and Nirwandar, Sapta and Almansori, Bubaker B. Hamad (2019) Optimization and formulation of Fucoxanthin-Loaded Microsphere (F-LM) using Response Surface Methodology (RSM) and analysis of its fucoxanthin release profile. Molecules, 24 (5). pp. 1-16. ISSN 1420-3049
  • Syed Hassan, Sharifah Sariah and Adam, Fatmawati and Abu Bakar, Mohd Rushdi and Abdul Mudalip, Siti Kholijah (2019)Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals. Journal of Saudi Chemical Society, 23 (2). pp. 239-248. ISSN 1319-6103
  • Ab Ghani, Salinda and Abu Bakar, Noor Fitrah and Abu Bakar, Mohd Rushdi and Yusof, Yus Aniza and Abdul Rahman, Norazah (2018) Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]. Malaysian Journal of Analytical Sciences, 22 (2). pp. 318-325. ISSN 1394-2506
  • Ab. Hadi, Hazrina and Abdullah, Nurul Shazwani and Ahmed, Qamar Uddin (2018) Exploring the tropical plant wealth: skin and health benefits. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 149-174. ISBN 9789674184544
  • Ab. Hadi, Hazrina and Azillah, Nurul Namira and Ahmed, Qamar Uddin (2018) Microsponge: a potential delivery system for salicylic acid in treating acne. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 127-148. ISBN 9789674184544
  • Ab. Hadi, Hazrina and Azman, Amirah (2018) A step forward to develop pharmacist with cosmeceutical knowledge in community pharmacy setting: a pilot study. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Ab. Hadi, Hazrina and Razak, Luqman (2018) Effects of smoking on skin conditions: in vivo assessment. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Ab. Hadi, Hazrina and Zamery, Muhammad 'Izzuddin and Zaiter, Ahmad (2018) Cosmeceutical applications of clay minerals: a review. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 275-296. ISBN 9789674184544
  • Abdul Kalam, Azad and Doolaanea, Abd Almonem and Al-Mahmood, Sinan Mohammed Abdullah and Wan Sulaiman, Wan Azizi and Al-Ani, Imad Matloub Dally (2018) Microencapsulation of peppermint oil using an ionic gelation electrospray technique. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Abdul Latif, Nurul Hazwani and Bakhtiar, M. Taher and Md Jaffri, Juliana and Amri, Mohamad Shahreen and Abdul Kudos, Muhammad Badri and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti (2018) Selected natural agents used for cholesterol controls. Nutrition & Food Science, 48 (2). pp. 301-317. ISSN 0034-6659
  • Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati and Che Man, Rohaida and Sulaiman, Siti Zubaidah and Mohd Arshad, Zatul Iffah and Md. Shaarani, Shalyda (2018) Effects of solvents on polymorphism and shape of mefenamic acid crystals. In: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017)., 6-7 Dec,2017, Penang.


Background

Big data in healthcare refers to electronic health data sets that are so large and
complex that it would be difficult to manage and analyze using traditional
software and data management tools and methods. Big data in healthcare is also
known as large health care databases which is one of the sources for drug
utilization study. It is often used to address research questions on drug use and
drug effect such as evaluation of the processes of prescribing, dispensing and
consumption of medicines to improve the quality use of medicines in populations.
Large healthcare databases, which contain data collected during routinely
delivered healthcare to patients, can serve as a valuable resource for generating
actionable evidence to assist in medical and healthcare policy decision-making.
The sources of large healthcare data include electronic medical records, health
insurance claims and patient registries. Data may be collected on drug sales,
prescriptions, drug distribution chain, pharmaceutical and medical billing. The
scope of the databases may be international, national or local. The databases
may be diagnosis-linked or non-diagnosis-linked. Diagnosis-linked data enable
drug use to be analyzed according to patient characteristics, therapeutic groups,
diseases or conditions and, in the best of cases, clinical outcome. A useful
analysis requires an understanding of the sources and organization of the data.
Harnessing the power of information contained in large healthcare databases,
while paying close attention to their inherent limitations, is critical to generate
rigorous evidence-base for medical decision-making and ultimately enhancing
patient care.

 


Scope of Research Activities

  1. To assess the quality of use and prescribing of medicines in healthcare settings.
  2. To describe and assess patterns of medication use and prescribing.
  3. To investigate the barriers and facilitators towards quality use of medicines.
  4. To conduct interventional studies to improve the quality of medication use and prescribing in healthcare settings.
  5. To promote and assess the awareness towards medication adherence, medicines information sources and health literacy.
  6. To investigate and assess pharmacists’ competencies, education and training that deemed necessary to perform their role in the quality use of medicines.


Leader and Members

  • Asst. Prof. Dr. Mohamed Hassan Elnaem (Leader)
  • Assoc. Prof. Dr. Mohamad Haniki Nik Mohamed
  • Asst. Prof. Dr. Muhammad Eid Akkawi
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas
  • Asst. Prof. Dr. Nor Hidayah Mohd Taufek
  • Asst. Prof. Dr. Nor Ilyani Mohamed Nazar
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Siti Hadijah Binti Shamsudin
  • Asst. Prof. Dr. Abdulkareem Mohammed Al-Shami
  • Asst. Prof. Dr. Tengku Karmila Tengku Kamil


Post graduate students

Open for recruitment


Laboratory(s) and Facility(s) 

  • Pharmacy practice laboratory and discussion room


Link and Collaboration

  • Department of Pharmacy, IIUMMC.
  • Department of Internal Medicine, Kulliyyah of Medicine, IIUM.
  • Department of Family Medicine, Kulliyyah of Medicine, IIUM.
  • AP. Dr. Hasniza Zaman Huri, Department of Pharmacy, University of Malaya
  • Dr. Noordin Othman, QUMPRG, Department of Clinical and Hospital Pharmacy, Taibah University, Saudi Arabia.


Community Services

  • Conduct home-medication review (HMR) for elderly patients Campaign to improve health literacy among the public focusing on cardiovascular disease prevention, diabetes and mental health.


Research Grant

  • Evaluation of the factors associated with lipid-lowering therapy use among patients with type 2 diabetes mellitus and the impact of academic detailing, 20,000 (2017): In Progress
  • Evaluation of lipid-lowering therapy use among patients with type 2 diabetes mellitus in Pahang, 20,000 (2016): completed. 
  • Development and Assessment of a Smartphone Application to Help Healthcare Providers Avoid Potentially Inappropriate Prescribing among Hospitalized Elderly Patients, 20,000 (2015): completed.


List of Selected Publications

  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Effectiveness and prescription pattern of lipid-lowering therapy and its associated factors among patients with type 2 diabetes mellitus in Malaysian primary care settings. Ther Clin Risk Manag. 2019; 18: 137–145.
  • Akkawi ME, Nik Mohamed MH, Md Aris MA, Does inappropriate prescribing affect elderly patients’ quality of life? a study from a Malaysian tertiary hospital. Qual Life Res. 2019.
  • Akkawi ME, Nik Mohamed MH, Are physicians and clinical pharmacists aware and knowledgeable enough about inappropriate prescribing for elderly patients? Findings from Malaysia. Eur J Hosp Pharm. 2018; 25, e29-e34.
  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Impact of educational outreach intervention on enhancing health care providers’ knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus. J Eval Clin Pract. 2018; 24: 521–527.
  • Akkawi ME, Nik Mohamed MH, Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community. Trop J Pharm Res. 2018; 17(1):151-160.
  • Elnaem MMH, Nik Mohamed MMH, Huri HZ, Azarisman SM. Patterns of statin therapy prescribing among hospitalized patients with Type 2 diabetes mellitus in two Malaysian tertiary hospitals. Trop J Pharm Res. 2017; 16: 3005–3011. 
  • Elnaem M, Nik Mohamed M, Huri HZ, Azarisman SM, Elkalmi RM. Statin therapy prescribing for patients with type 2 diabetes mellitus: A review of current evidence and challenges. J Pharm Bioallied Sci. 2017; 9: 80.

To be Updated